buy Apcalis (Tadalafil ) 20mg Cialis (tadalafil) is a cGMP-Specific Phosphodiesterase (PDE5) Type 5 Inhibitor used in the treatment of erectile dysfunction (ED) and benign prostatic hyperplasia (BPH).
ED is characterized by a man’s inability to achieve an erection or maintain a sufficient hard and erect penis for a gratifying sexual experience. BPH symptoms include a frequent need to urinate, painful urination or a feeling that the bladder has not fully emptied after urination.
How does Cialis work?
buy Apcalis (Tadalafil ) 20mg Cialis works by allowing the blood vessels in your penis to relax following sexual stimulation, enhancing blood flow into the penile tissues. This results in improved erections for satisfactory penetration and sexual performance.
It is essential to understand that Cialis only works in response to sexual stimulation, which is just as well. The mechanism behind the improved blood flow to the penis is hinted at in the name of the drug class of Cialis, ‘PDE 5 inhibitor’. The PDE5 is an enzyme involved in the degradation of cGMP in the corpus cavernosum.
When sexual stimulation occurs nitric oxide (NO) is released in the corpus cavernosum which activates the enzyme guanylyl cyclase which in turns produces and increased level of cGMP. cGMP is responsible for smooth muscle relaxation and blood flow in the penis, creating a stiff erection. When the PDE5 enzyme is inhibited by tadalafil, the active ingredient in Cialis, it decreases the rate at which cGMP is broken down and thus improving and prolonging an erection.
Cialis will not have an effect unless there is a physical arousal upon sexual stimulation.