buy Ativan Generic 1 mg Lorazepam injection is used preoperatively in adults to produce sedation, relieve anxiety, and provide anterograde amnesia. Administration of lorazepam injection is especially useful in patients with preoperative anxiety who prefer diminished recall of events associated with the day of surgery. Lorazepam injection may be used in conjunction with atropine sulfate, opiate analgesics, other parenterally administered analgesics, commonly used anesthetics, and skeletal muscle relaxants.
Lorazepam is used IV for the management of status epilepticus and IV lorazepam or diazepam generally is considered the drug of choice for termination of this condition. The efficacy of IV lorazepam was established in 2 multicenter controlled trials in patients (mostly 18-65 years of age) with tonic-clonic status epilepticus, simple partial and complex partial status epilepticus, or absence status.
buy Ativan Generic 1 mg In a double-blind, randomized, active-control study in 58 patients with status epilepticus, efficacy of lorazepam (given as a 2-mg IV dose with an additional 2-mg IV dose if necessary) was compared with that of diazepam (given as a 5-mg IV dose with an additional 5-mg IV dose if necessary). In this study, 80 or 57% of patients receiving lorazepam or diazepam, respectively, were considered responders, defined as the percentage of patients in whom seizures were terminated within 10 minutes after administration of the drug and who continued to be seizure-free for at least an additional 30 minutes. When patients who did not respond to the initial doses of lorazepam or diazepam received an additional 2-4 mg of lorazepam or 5-10 mg of diazepam, respectively, the overall response rate increased to 93 or 86%, respectively. In addition, in another clinical study in adults with status epilepticus, 61, 57, and 76% of patients receiving 1, 2, and 4 mg of lorazepam, respectively, reportedly were responders (as defined above). Although IV diazepam has been used more extensively, some clinicians prefer IV lorazepam because of its more prolonged duration of effect. For continuing seizures, a long-acting anticonvulsant (e.g., IV phenytoin, IV fosphenytoin) can be added presumptively to IV benzodiazepine therapy for the management of status epilepticus.