buy IMOVANE ( ZOPICLONE) Zopiclone has quickly gained acceptance by practitioners and patients.9 In Alberta it is now the most frequently dispensed hypnosedative agent (47.4% of such agents compared with 0.1% to 28.7% for individual benzodiazepines).10 Investigators have found substantial increases in the use of zopiclone in Canada in the years 1996–1997, 1998–1999, and 2000–2001.11 It appears that the increases might have come at the expense of declining use of some benzodiazepines. In a 2003 lay review12 of Canadian pharmaceuticals, zopiclone ranked 30th among the top 100 generic drug products sold (nearly 1.5 million prescriptions of generic zopiclone), and the brand name Imovane ranked 74th (more than 500 000 prescriptions) of 100 brand-name drug products sold in Canada; only Ativan ranked higher (14th; approximately 2.5 million prescriptions) as a brand-name hypnosedative.12
Initial reports have proposed that zopiclone did not cause rebound or withdrawal phenomena or dependence.13–15 Postmarketing surveillance reports have been favourable.16,17 Some have indicated that “Z” drugs were less likely to be habit forming than benzodiazepines.18–20 However, animal data support the potential for addiction.21 Although not much has been published on this topic, a somewhat different picture has emerged with the few anecdotes, case series, and controlled studies. Parallels with other addictive substances have been heralded and reviewed.22,23
buy IMOVANE ( ZOPICLONE) provides examples of zopiclone abuse and addiction.24–31 In some circumstances, the drug was initiated at a standard dose of 7.5 mg daily but then increased. Most patients taking the drug suffered from pre-existing addiction or chemical abuse, or from underlying psychiatric disorders. Withdrawal symptoms were reported in several of these anecdotes, including cravings, severe rebound insomnia, anxiety or panic attacks, weakness, tremor, palpitations, and tachycardia. Withdrawal seizures were also recorded.