buy Tramadol 250mg (Ultram)

buy Tramadol 250mg (Ultram) ULTRAM (tramadol hydrochloride) tablets are an opioid agonist. The chemical name for
tramadol hydrochloride is (±)cis-2-[(dimethylamino)methyl]-1-(3-methoxyphenyl)
cyclohexanol hydrochloride. The structural formula is:
The molecular weight of tramadol hydrochloride is 299.8. Tramadol hydrochloride is a
white, bitter, crystalline and odorless powder. It is readily soluble in water and ethanol
and has a pKa of 9.41. The n-octanol/water log partition coefficient (logP) is 1.35 at pH
7. ULTRAM tablets contain 50 mg of tramadol hydrochloride and are white in color.
Inactive ingredients in the tablet are pregelatinized corn starch, modified starch (corn),
hypromellose, lactose, magnesium stearate, microcrystalline cellulose, polyethylene
glycol, polysorbate 80, sodium starch glycolate, titanium dioxide and carnauba wax.
CLINICAL PHARMACOLOGY
Mechanism of Action
buy Tramadol 250mg (Ultram) ULTRAM contains tramadol, an opioid agonist and inhibitor of norepinephrine and
serotonin re-uptake. Although the mode of action is not completely understood, the
analgesic effect of tramadol is believed to be due to both binding to µ-opioid receptors
and weak inhibition of re-uptake of norepinephrine and serotonin.
Opioid activity is due to both low affinity binding of the parent compound and higher
affinity binding of the O-demethylated metabolite M1 to µ-opioid receptors. In animal
models, M1 is up to 6 times more potent than tramadol in producing analgesia and 200
times more potent in µ-opioid binding. Tramadol-induced analgesia is only partially
antagonized by the opiate antagonist naloxone in several animal tests. The relative
contribution of both tramadol and M1 to human analgesia is dependent upon the plasma
concentrations of each compound (see CLINICAL PHARMACOLOGY;
Pharmacokinetic

ULTRAM (tramadol hydrochloride) tablets are an opioid agonist. The chemical name for
tramadol hydrochloride is (±)cis-2-[(dimethylamino)methyl]-1-(3-methoxyphenyl)
cyclohexanol hydrochloride.
buy Tramadol 250mg (Ultram)

Tramadol-induced analgesia is only partially
antagonized by the opiate antagonist naloxone in several animal tests.

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